Metastasis: recent discoveries and novel treatment strategies. The lungs are the most common site of metastasis in melanoma ( 2 2. Therapy for metastatic melanoma: the past, present, and future. Although metastasis only occurs in approximately 10% of melanoma patients, it remains the major cause of death ( 1 1. Metastasis is the key factor in determining the stage, relevant treatment, and prognosis of most solid cancers. These data suggested that Notch ligand Dll1 may enhance the adhesion and metastasis of melanoma cells by upregulation of N-cadherin.ĭelta-like 1 Notch signaling Melanoma Metastasis Adhesion N-cadherin Along with increased Dll1 expression, N-cadherin, but not E-cadherin, was upregulated in B16-Dll1 cells. B16-Dll1 cells also had a higher metastatic potential than their counterpart in the mouse model of lung metastasis. Dll1 overexpression activated Notch signaling in B16 tumor cells and significantly enhanced the adhering capacity of B16 tumor cells both in vitro and in vivo. In this article, we extended our study to investigate the effects of Dll1 on tumor cell adhesion and metastasis. Previous research by our group indicated that Notch ligand Delta-like 1 (Dll1) is involved in angiogenesis in melanoma, and we noticed that it took a longer time to trypsinize Dll1-expressing B16 melanoma cells than the control cells. Notch signaling plays a vital role in tumorigenicity and tumor progression by regulating proliferation, invasion, and the tumor microenvironment. Shanĭepartment of Orthopedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China About the authors Fanĭepartment of Orthopedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China L.Q. Zhouĭepartment of Orthopedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China Q.Y.
Maĭepartment of Orthopedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China Y. Qiuĭepartment of Orthopedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China B.A. These authors contributed equally to this study.ĭepartment of Oncology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Chinaĭepartment of Orthopedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China X.C. Department of Orthopedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China
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